Moore, M. M., Abraham, I., Ballantyne, M., Behrsing, H., Cao, X., Clements, J., Gaca, M., Gillman, G., Hashizume, T., Heflich, R. H., et al. (2023). Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters. Altern Lab Anim 51(1), 55-79.
Patel, V. S., Amin, K., Wahab, A., Marimoutou, M., Ukishima, L., Alvarez, J., Battle, K., Stucki, A. O., Clippinger, A. J., and Behrsing, H. P. (2023). Cryopreserved Human Precision-cut Lung Slices Provide an Immune Competent Pulmonary Test System for "On-demand" Use and Long-term Cultures. Toxicol Sci doi: 10.1093/toxsci/kfac136.
Miller-Holt, J., Behrsing, H. P., Clippinger, A. J., Hirn, C., Stedeford, T. J., and Stucki, A. O. (2022). Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of tobacco and other nicotine-containing products. Front Toxicol 4, 943358.
Behrsing, H. P., Wahab, A., Ukishima, L., Grodi, C., Frentzel, S., Johne, S., Ishikawa, S., Ito, S., Wieczorek, R., Budde, J., et al. (2022). Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance. Altern Lab Anim doi: 10.1177/02611929221114383, 2611929221114383.
Miller-Holt, J., Behrsing, H., Crooks, I., Curren, R., Demir, K., Gafner, J., Gillman, G., Hollings, M., Leverette, R., Oldham, M., et al. (2022). Key Challenges for In vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for Dosimetry. Drug Test Anal doi: 10.1002/dta.3344.
Patel, V., Amin, K., Allen, D., Ukishima, L., Wahab, A., Grodi, C., Behrsing, H., Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation. Altern Lab Anim. 2021: 49, 209-222. https://doi.org/10.1177/02611929211061884
Thorne D, Adamson J, Sticken ET, Roman Wieczorek, Holger Behrsing, et al. An interlaboratory in vitro aerosol exposure system reference study. Toxicology Research and Application. January 2021. https://doi.org/10.1177/2397847321992752
Gary Phillips, Lukasz Czekala, Holger P Behrsing, Khalid Amin, Jessica Budde, Matthew Stevenson, Roman Wieczorek, Tanvir Walele, Liam Simms. Acute electronic vapour product whole aerosol exposure of 3D human bronchial tissue results in minimal cellular and transcriptomic responses when compared to cigarette smoke. Toxicology Research and Application 2021: 5; January 2021. https://doi.org/10.1177/2397847320988496
Behrsing, H., Hill, E., Curren, R. Human Precision Cut Lung Slices Can Provide Important Information to Toxicologists. Commentary. Applied In Vitro Toxicology. 2020: 6(3):75-76. http://doi.org/10.1089/aivt.2020.0019
T. Aghaloo, J.J. Kim, T. Gordon, H.P. Behrsing. In Vitro Models, Standards, and Experimental Methods for Tobacco Products. Advances in Dental Research 2019: 30(1):16-21
Holger Behrsing, Mario Aragon, Jason Adamson, Devin Sheehan, Marianna Gaca, Rodger Curren, and Erin Hill. Characterization of a Vitrocell VC1 Using Nicotine Dosimetry: An Essential Component Toward Standardized In Vitro Aerosol Exposure of Tobacco and Next Generation Nicotine Delivery Products. Applied In Vitro Toxicology 2018: 4;1-8.
Clippinger, A. (Moderator), Allen, D., Behrsing, H., Hinderliter, P., Landsidel, R, Reinke, E., Stone, V. (Participants). Nonanimal Approaches to Assessing the Toxicity of Inhaled Substances: Current Progress and Future Promise. Applied In Vitro Toxicology 2018: 4;82-88.
Clippinger, A.J., Allen, D., Behrsing, H., et al. Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicol In Vitro 2018: 52, 131-145.
Behrsing H, Hill E, Raabe H, et al. In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use. Altern Lab Anim 2017:45;117-158.
Guo L, Hamre J, 3rd, Eldridge S, Behrsing, HP et al. Editor's Highlight: Multiparametric Image Analysis of Rat Dorsal Root Ganglion Cultures to Evaluate Peripheral Neuropathy-Inducing Chemotherapeutics. Toxicol Sci 2017:156;275-288.
Behrsing HP, Huang S, Constant S. The Use of Human 3D Reconstructed Airway Cultures for Tobacco Product Evaluation: Precision Low-Volume Exposures at the Apical Site. Applied In Vitro Toxicology 2017:3;1-12.
Behrsing H, Raabe H, Manuppello J, et al. Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use. Altern Lab Anim 2016:44;129-166.
Covey JM, Reid JM, Buhrow SA, Kuffel M, Walden C, Behrsing HP, and Ames MM. Comparative Metabolism of Batracylin (NSC 320846) and N-acetylbatracylin (NSC 611001) Using Human, Dog, and Rat Preparations In Vitro. J Drug Metab Toxicol 2015:7.
Facundo M. Cutuli and Holger P. Behrsing. Compound-Specific Toxicities Detected in CFU-GM, Rat Kidney NRK Cells, Rat Bladder RBLAK Cells, and Rat Liver Slices following Batracylin or N-Acetyl Batracylin Exposure. Advances in Toxicology, Volume 2014 Article ID 283749 (2014)
Kaur, G., Behrsing, H., Parchment, R. E., Millin, M. D. and Teicher, B. A. Analyses of the combination of 6-MP and dasatinib in cell culture. Int J Oncol, Jul;43(1):13-22 (2013)
Holger P. Behrsing, Michael J. Furniss, Myrtle Davis, Joseph E. Tomaszewski and Ralph E. Parchment. In Vitro Exposure of Precision-Cut Lung Slices to 2-(4-Amino-3-Methylphenyl)-5-Fluorobenzothiazole Lysylamide Dihydrochloride (NSC 710305, Phortress) Increases Inflammatory Cytokine Content and Tissue Damage Toxicol. Sci. 131(2): 470-47(2013)
Augusto Pessina, Arianna Bonomi, Loredana Cavicchini, Beatriz Albella, Laura Cerrato, Dominique Parent-Massin, Yann Sibiril, Ralph Parchment, Holger Behrsing, Paolo Verderio, Sara Pizzamiglio, Manuela Giangreco, Carolina Baglio, Valentina Coccè, Francesca Sisto, and Laura Gribaldo. Prevalidation of the Rat CFU-GM Assay for In Vitro Toxicology Applications. ATLA 38, 105–117 (2010)
Holger Peter Behrsing, Michael J. Furniss, Kristine A. Robillard, Joseph E. Tomaszewski, Ralph E. Parchment. In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines. Cancer Chemother Pharmacol, May;65(6):1083-91(2010)
K. Amin, C. Ip, L. Jimenez, C.A. Tyson, and H.P. Behrsing. Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system. Toxicologic Pathology 34:776-784 (2006)
Holger P. Behrsing, Jennifer Tam, Brad Gray, Andy Do, Young Park, Hyoung Yun, Delai Zhao, Charles Gropper, Jaeho Jung, Robert G. Gish, Brendan M. McGuire, Angela Panoskaltsis-Mortari, George K. K. Lau, Young-Suk Lim, Han Chu Lee, Dong-Jin Suh, Sung-Soo Park. In Vitro Assessment of a Novel Porcine Liver Slice-filled Bio-artificial Liver (BAL) for Dialysis of Liver Failure Patients. Free Paper Session III. Journal of Gastroenterology and Hepatology 21 (s2), A88-A92. (2006)
H.P. Behrsing, K. Amin, C. Ip, L. Jimenez, and C.A. Tyson. In vitro detection of differential and cell-specific hepatobiliary toxicity induced by geldanamycin and 17-allyaminogeldanamycin in rats. Toxicology In Vitro Dec;19(8):1079-88 (2005)
H.P. Behrsing and P.R. Vulliet. Mitogen-activated protein kinase mediates purinergic-enhanced nerve growth factor-induced neurite outgrowth in PC12 cells. Journal of Neuroscience Research Oct 1;78(1):64-74 (2004)
H.P. Behrsing, A.E. Vickers, and C.A. Tyson. Extended rat liver slice survival and stability monitored using clinical biomarkers. Biochemical Biophysical Research Communication 213, 209-213 (2003)
H.P. Behrsing and P.R. Vulliet. Purinergic and calcium-mediated enhancement of NGF-induced neurite expression in PC12 cells. Proceedings of Western Pharmacology Society 42, 59-62 (1999)
T. Blank, I. Nijholt, U. Teichert, H. Kügler, H. Behrsing, A. Fienberg, P. Greengard, and J. Spiess. The phosphoprotein DARPP-32 mediates CAMP-dependent potentiation of striatal N-methyl-D-aspartate responses. Proceedings of National Academy of Science USA 94:14859-14864 (1997).
